Behaviour of LipL46 in Triton X-114. Triton X-114 fractions of L. interrogans organisms were separated by SDS-PAGE, and probed with LipL46 and LipL32 antisera (a), and LipL46 and LipL31 antisera (b). LipL32 and LipL31 are markers for the leptospiral outer and cytoplasmic membranes, respectively. (a, b) The fractions analysed are shown in the lanes labelled as follows: W, whole organism; P, Triton-X-114-insoluble pellet; A, aqueous-phase material; D, detergent-phase material. The number of cell equivalents was the same in all four lanes. Locations of molecular size standards (kDa) are shown on the left. Most of the LipL46 protein solubilized by Triton X-114 partitioned into the detergent phase.