Table 4.
Resistance factors of transfected HEK293 cells to chemotherapeutic agents.
| Resistance factorsa |
|||||
|---|---|---|---|---|---|
| Drugs | WT-MRP1/ABCC1 | Cys43Ser (128G>C) | Thr73lle (218C>T) | Arg723Gln (2168G>A) | Arg1058Gln (3173G>A) |
| Cisplatin | 0.95±0.24 | 0.95±0.14 | 0.83±0.18 | 0.76±0.20 | 1.10±0.10 |
| Paclitaxel | 1.14±0.09 | 0.99±0.16 | 0.99±0.21 | 1.10±0.22 | 1.04±0.16 |
| Daunorubicin | 17.82±3.15 | 17.27±2.37 | 19.73±1.98 | 9.09±1.68 | 8.73±2.62 |
| Doxorubicin | 14.38±0.75 | 15.13±0.91 | 14.63±1.52 | 3.63±1.20 | 2.38±1.03 |
| Etoposide | 12.65±2.09 | 11.51±1.92 | 13.08±1.84 | 4.41±0.67 | 6.65±1.05 |
| Methotrexate | 10.80±1.33 | 10.50±1.58 | 6.70±0.95 | 6.20±0.90 | 10.70±1.26 |
| Vinblastine | 5.44±1.36 | 5.72±1.60 | 5.64±1.04 | 2.80±1.26 | 5.44±1.62 |
| Vincristine | 11.35±3.11 | 11.17±2.91 | 8.89±2.40 | 3.76±1.15 | 11.18±2.82 |
a
Resistance factors=IC50 of wild-type or mutant MRP1/ABCC1 transfected cells/IC50 of empty vector control transfected cells.