Table 5.
Resistance factors of transfected CHO-K1 cells to chemotherapeutic agents.
| Resistance factora |
|||||
|---|---|---|---|---|---|
| Drugs | WT-MRP1/ABCC1 | Cys43Ser (128G>C) | Thr73lle (218C>T) | Arg723Gln (2168G>A) | Arg1058Gln (3173G>A) |
| Cisplatin | 0.94±0.05 | 0.98±0.12 | 0.89±0.04 | 0.99±0.09 | 0.89±1.10 |
| Paclitaxel | 0.94±0.11 | 0.88±0.10 | 0.96±0.05 | 1.00±0.07 | 0.96±0.06 |
| Daunorubicin | 12.97±2.76 | 13.09±2.68 | 13.07±2.81 | 2.96±0.58 | 4.81±1.01 |
| Doxorubicin | 15.44±1.37 | 15.84±0.91 | 15.44±1.95 | 6.46±0.90 | 7.22±0.86 |
| Etoposide | 16.57±1.91 | 16.44±1.95 | 4.84±0.51 | 3.56±0.36 | 4.77±0.56 |
| Methotrexate | 3.78±1.07 | 3.70±1.01 | 3.60±1.39 | 3.75±1.08 | 1.67±0.53 |
| Vinblastine | 10.35±1.61 | 10.32±1.70 | 10.27±1.66 | 5.73±0.87 | 8.50±1.32 |
| Vincristine | 6.93±1.13 | 6.78±1.18 | 6.79±1.04 | 2.27±0.34 | 6.85±1.14 |
a
Resistance factors=IC50 of wild-type or mutant MRP1/ABCC1 transfected cells/IC50 of empty vector control transfected cells.