Figure 1.

Overview of the CLK1 and CLK3 Structures

(A) Structure of the CLK1 kinase domain. Specific structural insertions defining the LAMMER kinases are highlighted by different colors and are labeled. The inhibitor debromohymenialdisine is shown in stick representation.

(B) Structural superimposition of the nonphosphorylated CLK1 (red) and CLK3 structures (blue).

(C) Sequence identity among the members of the human CLK family.

(D) Surface residue conservation mapped onto the CLK1 structure. Residues conserved among all CLK family members are shown in red, conserved hydrophobic residues in yellow, conserved polar residues in green and regions of diversity are shown in gray. A sequence alignment is shown in Supplemental Data.