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(A) Trimethoprim drug predicted to bind M. leprae dihydrofolate reductase (UniProt identifier Q9CBW1). (B) Vorinostat drug predicted to bind L. major histone deacetylase (UniProt identifier Q4QCE7). The original PDB structure with the ligand bound is shown in blue; the transferred binding site in the template structure is shown in green; and a comparative protein structure model of the target sequence is shown in magenta.
