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. 2009 Feb 19;18(9):1600–1611. doi: 10.1093/hmg/ddp076

Figure 8.

Figure 8.

ICV injection of 2′-O-methyl bifunctional RNA increases weight in a severe mouse model of SMA. (A) 2 PND severe mice were ICV-injected on PND 2, 4 with 6 µg of either Tra2-E1 or Selex activation RNA. Mice were weighed everyday post-first injection and graphed. (B) Kaplan–Meier survival curve depicts a trend towards increased life expectancy for Tra2-E1-injected mice (Mantel–Cox P = 0.03). (C) Percent weight gained post-first injection until maximal weight was graphed. Tra2-E1-injected mice showed a significant weight gain from birth to peak over non-injected and a negative control (Selex act) injected (one-way ANOVA P = 0.0006). There is a significant difference between Tra2-E1- and Selex act-injected mice (t-test P = < 0.0001).