Fig. 3.

Hematide induces significant changes in haematocrit (Hct) and secondary haematologic indices. Alterations in Hct, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) were assessed after intravenous administration of vehicle (○), 0.1 (•), 1.0 (□) or 10 (▪) mg Hematide/kg every 3 weeks to female rats for 6 months. Mean data ± standard deviation is presented with arrows denoting days of administration. For 0 through 1 mg/kg, 9 to 10 rats were sampled per dose per time-point through Days 188, Day 195 represented 19–20 animals while the remaining time-points represented 4–5 animals. Five to 10 rats were sampled per dose group for each time-point for the 10 mg/kg group. The spikes on Days 85 and 195 are related to samples taken soon after dosing (5 days) compared to the other time-points which were generally taken 2 days preceding dosing.