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. Author manuscript; available in PMC: 2010 Apr 9.
Published in final edited form as: J Med Chem. 2009 Apr 9;52(7):1943–1952. doi: 10.1021/jm801503n

Table 2.

Modification of C-3 position (replacing hydroxyl to alkyl or aryl) on triazoles

Compound Lantha Screen Kinase activity assay, IC50 (μM) pepJIP1 DELFIA displacement assay, IC50 (nM)
7a 27 108
7b 2 83
7c 7.9 168
7d 13.6 57
7e > 50 107
7f 3.1 122
7g 100 131