Figure 6. Nicotine attenuates renal injury in vagotomized animals following I/R injury.
Previously vagotomized rats underwent I/R surgery following pretreatment with either saline (vehicle) or nicotine (Nic, 1.5 mg kg−1). Pretreatment with nicotine significantly reduced the tubular necrosis scores. The nicotine dose was chosen based on previous dose–response experiments. Values are expressed as mean±s.e.m. (n = 6 rats per group). **P<0.0001.