Table III.

Summary of all proteins that either are functionally associated with each other in the same pathway or have an association with an HSA21 protein or a DS phenotype among the 52 significantly differing proteins shown in Table 1

Aβ, amyloid beta; APP, amyloid precursor protein.

Protein	Pathway	Association with HSA21 protein	Possible Down syndrome phenotype	Ref.
ASS1, SMS, GLUD1	Proline and arginine metabolism	Unknown	Unknown	31
PDIA3, CALR, CTSB	Antigen presentation	Unknown	Immune defects	31
RCN1	NFAT/calcineurin	DSCR1	Developmental defects	38, 39
FASCIN-1, HSPB1 (HSP27), ANXA5, GSTO1	Cytoskeletal remodeling and regulation	TIAM1 and either DSCR3, DSCR5, TTC3, and/or DYRK1A	Unknown	11, 40
LRPAP1, LRP2	Aβ clearance	APP	Alzheimer disease	34, 35
CTSB	APP cleavage (β-secretase action)	APP	Alzheimer disease	33