Table V.
Longitudinal changes during wild-type and R6/2 development: amount of protein
Only proteins altered by >10% of spot volume and p < 0.05 are indicated. An unpaired Student's t test was used to determine statistical significance. Changes within the group of HD or control were considered. Adjacent age stages were compared with each other.
| Age | Amount of protein isoforms altered
|
||
|---|---|---|---|
| Up | Down | Total | |
| weeks | % | ||
| A. R6/2 | |||
| 2/4 | 8.5 | 7.8 | 16.3 |
| 4/6 | 0.9 | 1.2 | 2.1 |
| 6/8 | 2.7 | 3.2 | 5.9 |
| 8/12 | 2.2 | 2.0 | 4.2 |
| B. Wild type | |||
| 2/4 | 6.8 | 6.5 | 13.3 |
| 4/6 | 0.8 | 2.2 | 3.0 |
| 6/8 | 8.0 | 6.1 | 14.1 |
| 8/12 | 3.4 | 2.8 | 6.2 |