Table VIII.
Pathways enriched at each stage and during disease progression
A KEGG pathway analysis was carried out, and only pathways with three or more proteins and p < 0.01 were included. Pathways marked bold were altered in at least four of five time points studied.
| Age | Pathways | Number of proteins |
|---|---|---|
| weeks | ||
| A. Pathways up-regulated | ||
| 2 | Glycolysis/gluconeogenesis | 9 |
| Pentose phosphate pathway | 4 | |
| Citrate cycle (tricarboxylic acid cycle) | 4 | |
| Glutamate metabolism | 4 | |
| 4 | Glycolysis/gluconeogenesis | 3 |
| Oxidative phosphorylation | 3 | |
| 6 | No pathways | |
| 8 | Glycolysis/gluconeogenesis | 5 |
| Citrate cycle (tricarboxylic acid cycle) | 4 | |
| Proteasome | 3 | |
| Tryptophan metabolism | 3 | |
| 12 | Proteasome | 10 |
| Glycolysis/gluconeogenesis | 5 | |
| Citrate cycle (tricarboxylic acid cycle) | 3 | |
| Cell communication | 3 | |
| B. Pathways down-regulated | ||
| 2 | Regulation of actin cytoskeleton | 3 |
| Proteasome | 3 | |
| 4 | Gap junction | 2 |
| 6 | No pathways | |
| 8 | Oxidative phosphorylation | 3 |
| 12 | Regulation of actin cytoskeleton | 6 |
| Glycolysis/gluconeogenesis | 5 | |
| Axon guidance | 3 | |
| Pyruvate metabolism | 3 |