Table 1.
Class I HDAC complexes from different eukaryotic organisms
| Complex | Mammal | Drosophila | C. elegans | S. cerevisiae | S. pombe | Arabidopsis | Protein domain | ||
|---|---|---|---|---|---|---|---|---|---|
| Rpd3L | Rpd3S | I | II | ||||||
| Sin3 | HDAC1/2 | dRpd3 | ceHda-1 | Rpd3 | Rpd3 | Clr6 | Clr6 | Rpd3 | Class I deacetylase |
| RbAp46/48 | p55 | Rba-1, Lin-53 | Ume1 | Ume1 | Prw1 | Prw1 | WD40 repeat | ||
| Sin3A | dSin3 | Sin3 | Sin3 | Sin3 | Pst1 | Pst2 | AtSin3 | PAH motifs | |
| Sds3/BRMS1 | Sds3 | Sds3 | Sds3 | Coiled coil | |||||
| RBP1 | |||||||||
| SAP30 | Sap30 | ||||||||
| SAP18 | AtSap18 | Ubiquitin-fold | |||||||
| ING1/2 | Pho23 | Png2 | PHD finger | ||||||
| Rco1 | PHD finger | ||||||||
| Eaf3 | Chromodomain | ||||||||
| Cph1 | PHD finger | ||||||||
| Cph2 | PHD finger | ||||||||
| Alp13 | Chromodomain | ||||||||
| Mi2/NuRD | HDAC1/2 | dRpd3 | ceHda-1 | Rpd3 | Rpd3 | Clr6 | Clr6 | Rpd3 | Class I deacetylase |
| RbAp46/48 | p55 | Rba-1, Lin-53 | WD40 repeat | ||||||
| Mi-2α/β | dMi-2 | Chd-3/-4 | Pickle | Helicase | |||||
| MTA1/2/3 | Egl-1, Egl-27 | SANT domain | |||||||
| MBD3 | Methyl CpG binding | ||||||||
| p66α/β | p66 | ||||||||
| CoREST | HDAC1/2 | dRpd3 | ceHda-1 | Rpd3 | Rpd3 | Clr6 | Clr6 | Rpd3 | Class I deacetylase |
| CoREST | dCoREST | Spr-1 | SANT domain | ||||||
| LSD1 | Su(Var)3-3 | Spr-5 | SWIRM, K-demethylase | ||||||
| BHC80 | PHD finger | ||||||||
| CtBP1 | Dehydrogenase | ||||||||
| N-CoR/SMRT | HDAC3 | dHDAC3 | Class I deacetylase | ||||||
| N-CoR/SMRT | SMRTER | SANT domain | |||||||
| TBL1/TBLR1 | WD40 repeat | ||||||||
| GPS2 | |||||||||
| JMJD2A | Jumonji demethylase | ||||||||
| Kaiso | Methyl CpG binding | ||||||||
Notes: For the mammalian and yeast complexes, only those subject to biochemical purification are listed here. For complexes in Drosophila, C. elegans and Arabidopsis, little biochemical purification has been performed, so the listed subunits are based on sequence and functional similarity with counterparts in yeast and mammals. In the CoREST complex, there is only a sub-stoichiometric amount of CtBP1, and so are JMJD2A and Kaiso in N-CoR/SMRT complexes.
Abbreviations used (in an alphabetical order): BHC80, an 80-kDa subunit of the BRAF-histone deacetylase complex; BRMS1, breast cancer metastasis suppressor 1, similar to SDS3; ceHda-1, C. elegans HDAC1-related protein; CoREST, corepressor of REST (repressor element 1 silencing transcription factor); CtBP1, E1A C-terminal binding protein 1; Eaf3, Esa1-associated factor 3; Hda1, histone deacetylase 1; ING1/2, inhibitor of growth 1 or 2; JMJD2A, jumonji demethylase D group member 2A; LSD1, lysine-specific demethylase 1; MBD3, methyl CpG-binding domain 3; Mit1, Mi2-like protein interacting with Clr three 1; MTA1, metastasis-associated protein 1; Mi2, dermatomyositis-specific autoantigen; NuRD, nucleosome remodeling deacetylase complex; PHD finger, plant homeodomain-linked zinc finger; PAH motif, paired amphipathic helix motif; Rba-1, RbAp48-related protein; Pst1, S. pombe SIN three 1; RBP1, Rb-binding protein 1; SANT domain: Swi3, Ada2, N-CoR, and TFIIIB homologous domain; SAP30, Sin3-associated polypeptide of 30 kDa; SDS3, suppressor of defective silencing 3; N-CoR, nuclear receptor co-repressor; Sin3, SWI-independent 3 (also known as Rpd1, for reduced potassium dependency 1); SMRT, silencing mediator of retinoic acid and thyroid hormone receptors; Su(var)3-3, suppressor of position-effect variegation 3-3; SWIRM domain, Swi3p, Rsc8p and Moira homologous domain; TBL1, transducin β-like protein 1; WD40 repeat, tryptophan-aspartate 40 repeat.