TABLE 4.

Relative risks and 95% CIs of coronary heart disease by consumption level of artificially sweetened beverages (n = 88,520)¹

	Consumption level
	<1/mo	1–4/mo	2–6/wk	1 to <2/d	≥2/d	P for trend
Median intake (servings/d)	0	0.1	0.4	1.2	2.5
No. of cases	1218	424	1040	278	145
Person-years	730,939	295,253	671,986	202,060	101,970
Age-adjusted	1	0.82 (0.74, 0.92)	0.88 (0.81, 0.96)	1.01 (0.88, 1.15)	1.28 (1.08, 1.53)	0.002
Multivariate-adjusted2	1	0.91 (0.81, 1.02)	0.96 (0.88, 1.05)	1.01 (0.88, 1.15)	1.14 (0.96, 1.36)	0.10
Multivariate-adjusted + diet3	1	0.92 (0.82, 1.03)	0.98 (0.90, 1.07)	1.03 (0.90, 1.17))	1.15 (0.97, 1.38)	0.07

¹Beverage consumption includes low-calorie caffeine- and non-caffeine-containing carbonated beverages. Relative risks were computed from a Cox proportional hazard model.

²Adjusted for age (continuous), smoking [never, past, or current cigarette use (1–14/d, 15–24/d, ≥25/d, or missing), alcohol intake (0, <5, 5–15, or >15 g/d), family history (yes or no), physical activity (quintiles), aspirin use (<1, 1–2, 3–6, 7–14, or ≥15/wk), menopausal status and postmenopausal hormone use (premenopausal, never, past, or current hormone use), and history of hypertension and high blood cholesterol.

³Additionally adjusted for the Alternate Healthy Eating Index (quintiles).