TABLE 3.

Phospholipid fatty acids at baseline in the HIV patients and in the non-HIV control groups¹

	HIV+subjects (n = 39)	Non-HIV healthycontrols (n = 13)	Non-HIV unhealthycontrols2 (n = 18)		Bonferroni-adjusted P values
Characteristic				OverallP value3	1 vs 3	1 vs 2	2 vs 3
14:0 (%nmol)	1.0 ± 3.14	0.6 ± 0.1	0.6 ± 0.2	0.71	—	—	—
16:0 (%nmol)	29.0 ± 2.7	36.5 ± 3.6	34.4 ± 2.7	<0.001	<0.001	<0.001	0.21
16:1n−7 (%nmol)	0.7 ± 0.3	0.4 ± 0.2	0.7 ± 0.4	0.011	0.99	<0.001	0.009
18:0 (%nmol)	14.7 ± 2.1	9.7 ± 2.1	12.0 ± 1.8	<0.001	<0.001	<0.001	0.003
18:1n−9 (%nmol)	12.7 ± 2.5	13.5 ± 1.7	13.2 ± 2.4	0.41	—	—	—
18:2n−6 (%nmol)	21.3 ± 3.1	24.1 ± 4.7	25.0 ± 4.1	0.003	0.001	0.12	0.99
18:3n−3 (%nmol)	0.26 ± 0.15	0.02 ± 0.04	0.04 ± 0.09	<0.001	<0.001	<0.001	0.99
20:3n−9 (%nmol)	0.26 ± 0.16	0.00 ± 0.00	0.03 ± 0.09	<0.001	<0.001	<0.001	0.60
20:3n−6 (%nmol)	3.9 ± 1.4	1.8 ± 1.3	1.1 ± 1.1	<0.001	<0.001	<0.001	0.30
20:4n−6 (%nmol)	11.5 ± 2.7	11.3 ± 2.1	10.8 ± 2.9	0.61	—	—	—
20:5n−3 (%nmol)	0.8 ± 0.7	0.2 ± 0.6	0.2 ± 0.3	<0.001	<0.001	0.012	0.99
22:4n−6 (%nmol)	0.37 ± 0.17	0.13 ± 0.12	0.12 ± 0.12	<0.001	<0.001	<0.001	0.99
22:5n−6 (%nmol)	0.32 ± 0.15	0.05 ± 0.09	0.04 ± 0.07	<0.001	<0.001	<0.001	0.99
22:5n−3 (%nmol)	0.7 ± 0.4	0.1 ± 0.1	0.2 ± 0.1	<0.001	<0.001	<0.001	0.40
22:6n−3 (%nmol)	2.5 ± 0.9	1.7 ± 0.9	1.6 ± 1.0	0.002	0.0021	0.015	0.99
Total 20:5n−3 + 22:6n−3 (%nmol)	3.3 ± 1.2	1.9 ± 1.0	1.8 ± 1.2	<0.001	<0.001	<0.001	0.99
Total SFAs (%nmol)	44.8 ± 3.1	46.8 ± 2.2	47.1 ± 2.6	0.010	0.012	0.03	0.99
Total MUFAs (%nmol)	13.4 ± 2.7	13.9 ± 1.7	13.9 ± 2.6	0.65	—	—	—
Total PUFAs (%nmol)	41.8 ± 2.6	39.3 ± 3.0	39.0 ± 2.7	<0.001	0.003	0.018	0.99
n−6 (%nmol)	37.4 ± 2.4	37.3 ± 3.0	37.0 ± 3.2	0.92	—	—	—
n−3 (%nmol)	4.2 ± 1.4	2.1 ± 1.1	2.0 ± 1.3	<0.001	<0.001	<0.001	0.99
n−6/n−3 Ratio	9.8 ± 3.1	20.7 ± 11.8	25.5 ± 21.0	<0.001	0.006	0.003	0.99
20:3n−9/20:4n−6 Ratio	0.03 ± 0.1	0.00 ± 0.00	0.00 ± 0.01	<0.001	<0.001	<0.001	0.54
Total PLs (nmol/mL)	5583 ± 1420	2729 ± 615	3072 ± 843	<0.001	<0.001	<0.001	0.54
Total TGs (nmol/mL)	8669 ± 5716	2726 ± 905	4186 ± 2066	<0.001	<0.001	<0.001	0.027

¹SFAs, saturated fatty acids; MUFAs, monounsaturated fatty acids; PUFAs, polyunsaturated fatty acids; PLs, phospholipids; TGs, triglycerides.

²Non-HIV unhealthy controls had elevated serum triglycerides (>150 mg/dL) and/or insulin resistance.

³Overall P values are from type 3 score statistics for continuous variables and chi-square test for categorical variables.

⁴Mean ± SD (all such values).