Table 4.
Quantification of tumor angiogenesis by stereology
vessel density (mm-2) |
Lv (mm-2) |
Vv (10-3) |
Sv (mm-1) |
|
control (n = 9) | 39.9 ± 18.5 | 77.2 ± 37.1 | 5.1 ± 2.5 | 2.6 ± 1.3 |
CHS 828a (n = 13) | 12.8 ± 10.3 | 25.6 ± 20.5 | 2.8 ± 2.1 | 1.0 ± 0.7 |
Changeb(%) | -67.1% ** | -67.1% ** | -44.7% | -62.7% * |
CHS 828 was administered at 20 mg/kg/day by oral gavage.
Lv, length of vessels per tumor volume (length density); Vv, volume of vessels per tumor volume (volumetric density); Sv, surface area of vessels per tumor volume (surface density). Mean ± 1SD, Mann-Whitney U test.
aCHS 828 treatment for 10 days
bChange compared to control
*p < 0.05 **p < 0.01