Table 2.
Analyses to be performed in the IPD meta-analyses.
| Topics | Postmenopausal bleeding | Preterm birth | Tubal pathology | Ovarian response in IVF |
|---|---|---|---|---|
| ROC analysis | -TVS* | -Cervical length* | -Age* | -Age* |
| -CAT* | -FSH* | |||
| -AFC* | ||||
| -AMH* | ||||
| Univariable analyses | All relevant patient characteristics | All relevant patient characteristics | All relevant patient characteristics | All relevant patient characteristics |
| Multivariable model patient characteristics only | -Age | -Age | -Age | -Age |
| -HRT use | -Obstetric history | -Fertility history | ||
| -BMI | -BMI | -PID | ||
| -Time since menopause | -Multiple pregnancies | -Ectopic pregnancy | ||
| -Diabetes | -Parity | -BMI | ||
| -Hypertension | -Diabetes | -Pelvic surgery | ||
| -Anticoagulants use | -Blood pressure | |||
| -Previous cancer | ||||
| -Thyroid dysfunction | ||||
| Tests in multivariable model with tests | -TVS | -Cervical length | -CAT | -AFC |
| -Hysteroscopy | -Fibronectin test | -HSG | -FSH | |
| -Laparoscopy | -AMH | |||
| Subgroup analysis | -BMI* | -Age* | -Age* | |
| -Diabetes | -PID | -Duration subfertility* | ||
| Duration subfertility* | -Type subfertility | |||
| -Type subfertility | -BMI* | |||
| -BMI* | ||||
| -CAT | ||||
| Diagnostic decision rules: | ||||
| 1. Patient characteristics rule | histology if ca > 3% | |||
| 2. Selective rule | TVS if ca > 3% → > 4 mm: histology | |||
| 3. Integrated rule | TVS and histology if ca > 3% | |||
| Decision analysis | -Patient characteristics | -Patient valuations | ||
| -Tubal pathology | -IVF success | |||
| Combined analyses | Combination with progesterone | Combination with IVF outcome | ||
Overview of variables and analyses that will be used, specified for each clinical topic. Marked variables (*) will also be assessed as continuous data.