Table 3.
Odds Ratios and 95%CI for DNA repair SNPs and risk of glioblastoma for all centers combined, Glioblastoma Collaborative Group, 2008
| Gene SNP | genotype | CAb (%) | COb (%) | ORc | 95%CI |
|---|---|---|---|---|---|
| Base Excision Repair | |||||
| APEX1 rs1130409 | |||||
| TT | 265 (26.8) | 535 (27.8) | ref | ||
| GT | 510(51.6) | 945 (49.1) | 1.09 | (0.90, 1.31) | |
| GG | 213(21.6) | 446(23.1) | 1.00 | (0.80, 1.25) | |
| p-trend=0.96 | |||||
| OGG1 rs1052133 | |||||
| CC | 596 (59.9) | 1150 (59.3) | ref | ||
| CG | 347 (34.9) | 676(34.9) | 0.96 | (0.81, 1.13) | |
| GG | 52 (5.2) | 112 (5.8) | 0.88 | (0.62, 1.25) | |
| p-trend=0.43 | |||||
| PARP1 rs1136410 | |||||
| TT | 713 (72.2) | 1303 (67.3) | ref | ||
| CT | 251 (25.4) | 575 (29.7) | 0.79 | (0.67, 0.95) | |
| CC | 23 (2.3) | 57 (3.0) | 0.83 | (0.51, 1.38) | |
| p-trend=0.02 | |||||
| XRCC1 rs25487 | |||||
| GG | 397 (39.6) | 844 (42.8) | ref | ||
| AG | 461 (46.0) | 865 (43.9) | 1.12 | (0.95, 1.33) | |
| AA | 145 (14.5) | 262 (13.3) | 1.23 | (0.96, 1.57) | |
| p-trend=0.07 | |||||
| XRCC1 rs1799782 | |||||
| CC | 842 (87.5) | 1664 (86.6) | ref | ||
| CT | 117(12.2) | 252 (13.1) | 0.89 | (0.70, 1.14) | |
| TT | 3 (0.3) | 6 (0.3) | 0.84 | (0.21, 3.45) | |
| p-trend=0.35 | |||||
| Direct Repair | |||||
| MGMT rs12917 | |||||
| CC | 774 (77.6) | 1480 (75.2) | ref | ||
| CT | 204 (20.4) | 453 (23.0) | 0.89 | (0.73, 1.07) | |
| TT | 20 (2.0) | 35 (1.8) | 1.24 | (0.70, 2.20) | |
| p-trend=0.50 | |||||
| Non Homologous End Joining | |||||
| PRKDC rs7003908 | |||||
| TT | 389 (41.8) | 811 (42.3) | ref | ||
| GT | 397 (42.6) | 875 (45.7) | 1.07 | (0.90, 1.27) | |
| GG | 145 (15.6) | 230 (12.0) | 1.44 | (1.13, 1.84) | |
| p-trend=0.009 | |||||
| Nucleotide Excision Repair | |||||
| ERCC1 rs3212986 | |||||
| CC | 557 (57.0) | 1087 (56.6) | Ref | ||
| CA | 361 (36.9) | 728 (37.9) | 0.99 | (0.84,1.17) | |
| AA | 59 (6.0) | 105 (5.5) | 1.09 | (0.77,1.54) | |
| p-trend=0.84 | |||||
| ERCC2 rs13181 | |||||
| AA | 376 (37.6) | 823 (41.8) | Ref | ||
| AC | 480 (48.0) | 891 (45.2) | 1.16 | (0.98, 1.37) | |
| CC | 143 (14.3) | 256 (13.0) | 1.19 | (0.93, 1.52) | |
| p-trend=0.08 | |||||
| ERCC5 rs17655 | |||||
| GG | 499 (49.7) | 989 (50.5) | ref | ||
| CG | 348 (34.7) | 657 (33.6) | 0.98 | (0.82, 1.18) | |
| CC | 157 (15.6) | 311 (15.9) | 0.81 | (0.60, 1.08) | |
| p-trend=0.25 | |||||
| GLTSCR1 rs1035938 | |||||
| CC | 503 (51.2) | 1017 (53.2) | ref | ||
| CT | 395 (40.2) | 761 (39.8) | 1.06 | (0.90, 1.25) | |
| TT | 84 (8.6) | 135 (7.1) | 1.24 | (0.92, 1.67) | |
| p-trend=0.18 | |||||
| RAD23B rs1805329 | |||||
| CC | 673 (68.3) | 1264 (65.7) | ref | ||
| CT | 277(28.1) | 573 (29.8) | 0.90 | (0.76, 1.07) | |
| TT | 36 (3.7) | 88 (4.6) | 0.71 | (0.47, 1.07) | |
| p-trend=0.07 | |||||
b
differences in numbers due to missing genotypes;
c
adjusted for age, gender and study center.