Table 1.
Descriptive characteristics of endometrial cancer cases and controls in the NHS and WHS1
| Variables | NHS cases (n=456) |
NHS controls (n=1134) |
WHS cases (n=137) |
WHS controls (n=411) |
|---|---|---|---|---|
| Age at biospecimen collection, mean (SD) | 59.4 (6.7) | 59.6 (6.6) | 56.9 (7.3) | 57.0 (7.3) |
| Age at menarche, mean (SD) | 12.5 (1.4) | 12.6 (1.4) | 12.4 (1.3) | 12.5 (1.4) |
| Menopausal status at diagnosis, n (%) | ||||
| Premenopausal | 90 (19.2) | 161 (14.1) | 15 (11.5) | 99 (24.1) |
| Postmenopausal | 371 (78.9) | 955 (83.3) | 110 (84.6) | 285 (69.3) |
| Dubious/missing | 9 (1.9) | 30 (2.6) | 5 (3.9) | 27 (6.6) |
| PMH use at diagnosis2, n (%) | ||||
| Never | 132 (37.9) | 411 (45.6) | 49 (36.8) | 227 (55.2) |
| Former | 66 (19.0) | 216 (24.0) | 26 (19.6) | 33 (8.0) |
| Current | 150 (43.1) | 274 (30.4) | 58 (43.6) | 151 (36.7) |
| Age at menopause, mean (SD) | 50.3 (4.3) | 49.7 (4.0) | 49.6 (4.5) | 49.5 (4.3) |
| BMI at diagnosis, kg/m, mean (SD) | 28.3 (7.0) | 25.8 (5.0) | 29.0 (7.3) | 25.6 (4.4) |
| Parity3, mean (SD) | 3.1 (1.4) | 3.3 (1.5) | 2.7 (1.3) | 2.8 (1.4) |
| Ethnicity/ancestry, n (%) | ||||
| Caucasian/Non-Hispanic | 434 (96.4) | 1057 (95.3) | 130 (96.3) | 391 (95.8) |
| African-American/Black | 1 (0.22) | 8 (0.72) | 2 (1.5) | 5 (1.2) |
| Asian/Pacific Islander | 3 (0.67) | 7 (0.63) | 1 (0.74) | 5 (1.2) |
| American Indian | 0 (0.0) | 9 (0.81) | 0 (0.0) | 2 (0.49) |
| Other | 12 (2.7) | 28 (2.5) | 2 (1.5) | 5 (1.2) |
| First-degree family history of colon cancer, n (%) | 99 (21.1) | 211 (18.4) | 9 (6.6) | 44 (10.7) |
| Ever OC use, n (%) | 176 (37.5) | 470 (41.0) | 70 (51.1) | 254 (62.1) |
| Smoking status at diagnosis, n (%) | ||||
| Never | 236 (50.9) | 502 (44.2) | 71 (55.5) | 206 (50.1) |
| Former | 169 (36.4) | 447 (39.3) | 36 (28.1) | 158 (38.4) |
| Current | 59 (12.7) | 188 (16.5) | 21 (16.4) | 47 (11.4) |
1
Numbers may not sum to total due to missing values
2
Among postmenopausal women
3
Among parous women