Table 3.
UGT2B7 polymorphisms and endometrial cancer risk in WHS and NHS1
| UGT2B7 polymorphisms | Cases, n (%) | Controls, n (%) | OR (95% CI)2 | Adjusted OR (95% CI)3 |
|---|---|---|---|---|
| UGT2B7 −79 G/A | ||||
| G/G | 479 (93.4) | 1256 (93.7) | 1.00 | 1.00 |
| G/A | 33 (6.4) | 85 (6.3) | -- | -- |
| A/A | 1 (0.20) | 0 | -- | -- |
| A carriers | 34 (6.6) | 85 (6.3) | 0.96 (0.63, 1.48) | 1.07 (0.67, 1.72) |
| UGT2B7 H268 Y | ||||
| H268/H268 | 134 (25.0) | 328 (23.5) | 1.00 | 1.00 |
| H268/Y268 | 243 (45.5) | 679 (48.6) | 0.84 (0.65, 1.08) | 0.87 (0.65, 1.15) |
| Y268/Y268 | 157 (29.4) | 390 (27.9) | 0.96 (0.72, 1.27) | 0.93 (0.67, 1.27) |
| P = 0.84 | P = 0.69 | |||
| Y268 carriers | 400 (74.9) | 1069 (76.5) | 0.88 (0.69, 1.12) | 0.89 (0.68, 1.16) |
1
The number of participants does not sum to total women because of missing data on genotype.
2
Conditional logistic regression model conditioned on the strata defined by the matching variables: age, menopausal status and postmenopausal hormone use at blood collection, date of blood draw, time of blood draw, and fasting status at blood draw.
3
Conditional logistic regression model conditioned on the strata defined by the matching variables and body mass index at diagnosis, age at menarche, age at menopause, menopausal status and postmenopausal hormone use at diagnosis, first-degree family history of colorectal cancer, parity, age at first birth, and smoking status.