Table 2.
Associations between clinicopathologic and molecular characteristics and CRC recurrence based on tumor stage
| Stage II |
Stage III |
|||||
|---|---|---|---|---|---|---|
| Variable | Number of Patients (%) |
χ2 P-value | Number of Patients (%) |
χ2 P-value | ||
| Without recurrence 68 (74%) | With recurrence 24 (26%) | Without recurrence 30 (45%) | With recurrence 36 (55%) | |||
| Age Group (years) | ||||||
| < 65 | 29 (43) | 14 (58) | 0.1854 | 15 (50) | 15 (42) | 0.4984 |
| ⩾ 65 | 39 (57) | 10 (42) | 15 (50) | 21 (58) | ||
| Gender | ||||||
| Male | 45 (66) | 17 (71) | 0.6757 | 21 (70) | 19 (53) | 0.1539 |
| Female | 23 (34) | 7 (29) | 9 (30) | 17 (47) | ||
| pT component of stage (bowel wall invasion) | ||||||
| pT1 | – | – | 0.0168 | 0 (0) | 1 (3) | 0.2893 |
| pT2 | – | – | 8 (27) | 4 (11) | ||
| pT3 | 54 (79) | 13 (54) | 13 (43) | 21 (58) | ||
| pT4 | 14 (21) | 11 (46) | 9 (30) | 10 (28) | ||
| pN component of stage (nodal involvement) | ||||||
| N0 | 68 (74%) | 24 (26%) | – | – | 0.7457 | |
| N1 | – | – | 18 (60) | 23 (64) | ||
| N2–3 | – | – | 12 (40) | 13 (36) | ||
| Tumor location | ||||||
| Colon | 51 (75) | 19 (79) | 0.6808 | 25 (83) | 26 (72) | 0.2835 |
| Rectum | 17 (25) | 5 (21) | 5 (17) | 10 (28) | ||
| Tumor size (cms) | ||||||
| ≤ 5 | 34 (50) | 13 (54) | 0.7255 | 21 (70) | 25 (69) | 0.9610 |
| > 5 | 34 (50) | 11 (46) | 9 (30) | 11 (31) | ||
| Tumor differentiation | ||||||
| Low grade | 59 (87) | 23 (96) | 0.2198 | 23 (77) | 27 (75) | 0.8750 |
| High grade | 9 (13) | 1 (4) | 7 (23) | 9 (25) | ||
| Bcl-2 expression | ||||||
| Low (ISS* < 0.5) | 19 (28) | 16 (67) | 0.0008 | 15 (50) | 19 (53) | 0.8221 |
| High (ISS ⩾ 0.5) | 49 (72) | 8 (33) | 15 (50) | 17 (47) | ||
| Vital status (at follow-up) | ||||||
| Alive | 33 (49) | 4 (17) | < 0.0001 | 15 (50) | 3 (8) | < 0.0001 |
| Colon Cancer** | 2 (2) | 17 (71) | 2 (7) | 29 (81) | ||
| Other*** | 33 (49) | 3 (12) | 13 (43) | 4 (11) | ||
*
ISS = Immuno staining score.
**
Dead due to colorectal cancer.
***
Death due to causes other than colorectal cancer or unknown.