Table 3.

Multivariate Cox regression analyses to assess the value of Bcl-2 expression in predicting risk of recurrence in Caucasian patients with colorectal cancer

	Recurrence within 5 Years			Recurrence within 10 Years
Variable	Crude HR	Adjusted* HR (95% CI)	P	Crude HR	Adjusted* HR (95% CI)	P
Stage II (n = 92)
Bcl-2 expression
Low vs. High	3.91	3.90 (1.55, 9.77)	0.0037	4.21	4.32 (1.74, 10.71)	0.0016
pT component of stage(bowel wall invasion)
pT4 vs. pT3	3.01	2.84(1.15, 7.00)	0.0234	2.82	2.80 (1.15, 6.84)	0.0237
Age group
⩾ 65 years vs. < 65 years	0.67	0.64(0.26, 1.55)	0.3203	0.74	0.70 (0.29, 1.65)	0.4112
Gender
Male vs. Female	1.74	1.21(0.43, 3.43)	0.7209	1.46	1.01 (0.38, 2.68)	0.9903
Tumor location
Rectum vs. Colon	1.06	0.79 (0.27, 2.34)	0.6755	1.01	0.81 (0.28, 2.38)	0.7080
Tumor differentiation
High grade vs. Low grade	2.23	2.75 (0.72, 3.94)	0.2876	2.14	2.32 (0.64, 3.34)	0.3213
Tumor size (cms)
> 5 vs. ≤ 5	0.73	0.70 (0.28, 1.76)	0.4541	0.82	0.80 (0.33, 1.95)	0.6263
Stage III (n = 66)
Bcl-2 expression
Low vs. High	1.19	1.07(0.47, 2.45)	0.8704	1.19	1.04 (0.47, 2.30)	0.9240
pN component of stage (nodal involvement)
N2–3 vs. N1	1.53	1.77(0.76, 4.13)	0.1833	1.38	1.66 (0.73, 3.77)	0.2266
pT component of stage (bowel wall invasion)
pT4 vs. pT3	1.16	0.75 (0.29, 1.96)	0.5606	1.04	0.75 (0.30, 1.91)	0.5528
Age group
⩾65 years vs. < 65 years	1.41	1.30 (0.57, 2.95)	0.5270	1.44	1.31 (0.59, 2.89)	0.5031
Gender
Male vs. Female	0.56	0.46 (0.20, 1.08)	0.0747	0.62	0.55 (0.24, 1.25)	0.1521
Tumor location
Rectum vs. Colon	1.15	1.18 (0.41, 3.41)	0.7570	1.25	1.29 (0.47, 3.50)	0.6222
Tumor differentiation
High grade vs. Low grade	1.41	1.52 (0.61, 3.78)	0.3711	1.33	1.36 (0.56, 3.32)	0.5001
Tumor size (cms)
> 5 vs. ≤ 5	1.53	1.36 (0.55, 3.34)	0.5049	1.39	1.22 (0.51, 2.95)	0.6574

^*Hazard ratios adjusted for Bcl-2 expression, depth of the tumor invasion into the bowel wall, number of lymph nodes involved, tumor differentiation, tumor size, tumor location, patient age, and gender.