Table 4.

Multivariate Cox regression analyses to assess the value of Bcl-2 expression in predicting the risk of mortality due to colorectal cancer in Caucasian patients

Variable	5 Year Survival			10 Year Survival
	Crude HR	Adjusted* HR (95% CI)	P	Crude HR	Adjusted* HR (95% CI)	P
Stage II (n = 92)
Bcl-2 expression
Low vs. High	7.68	8.48 (2.29, 31.45)	0.0014	4.33	5.77 (2.04, 16.33)	0.0009
pT component of stage (bowel wall invasion)
pT4 vs. pT3	5.58	6.37 (1.97, 20.60)	0.0020	5.65	7.96 (2.75, 23.01)	0.0001
Age group
⩾65 years vs. < 65 years	1.04	1.08 (0.36, 3.22)	0.8834	1.26	1.25 (0.47, 3.30)	0.6553
Gender
Male vs. Female	7.72	4.62 (0.58, 36.67)	0.1473	2.15	1.30 (0.40, 4.20)	0.6606
Tumor location
Rectum vs. Colon	0.86	0.47 (0.12, 1.87)	0.2847	0.67	0.47 (0.12, 1.83)	0.2756
Tumor differentiation
High grade vs. Low grade	3.25	3.48 (0.35, 5.21)	0.4715	3.78	3.92 (0.42, 4.92)	0.5187
Tumor size (cms)
> 5 vs. ≤ 5	0.68	0.52 (0.17, 1.60)	0.2542	0.92	0.76 (0.29, 1.99)	0.5722
Stage III (n = 66)
Bcl-2 expression
Low vs. High	1.62	1.52 (0.60, 3.88)	0.3810	1.50	1.35 (0.55, 3.32)	0.5115
pN component of stage (nodal involvement)
N2–3 vs. N1	2.14	3.42 (1.37, 8.51)	0.0083	1.99	2.92 (1.21, 7.07)	0.0176
pT component of stage (bowel wall invasion)
pT4 vs. pT3	0.94	0.56 (0.19, 1.60)	0.2783	1.05	0.63 (0.23, 1.76)	0.3836
Age group
⩾65 years vs. < 65 years	1.52	1.74 (0.70, 4.34)	0.2369	1.46	1.51 (0.62, 3.66)	0.3628
Gender
Male vs. Female	0.65	0.52 (0.20, 1.33)	0.1718	0.61	0.51 (0.20, 1.27)	0.1466
Tumor location
Rectum vs. Colon	1.21	1.19 (0.37, 3.89)	0.7692	1.18	1.16 (0.36, 3.73)	0.8050
Tumor differentiation
High grade vs. Low grade	1.36	1.29 (0.50, 3.33)	0.5994	1.32	1.25 (0.49, 3.23)	0.6390
Tumor size (cms)
> 5 vs. ≤ 5	2.18	1.78 (0.68, 4.62)	0.2366	2.04	1.63 (0.64, 4.17)	0.3070

^*Hazard ratios adjusted for Bcl-2 expression, depth of the tumor invasion into the bowel wall, number of lymph nodes involved, tumor differentiation, tumor size, tumor location, patient age, and gender.