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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Curr Opin Pharmacol. 2009 Jan 20;9(1):59–64. doi: 10.1016/j.coph.2008.12.003

Table 1.

The role of glutamate receptor subtypes in the reinstatement of cocaine-, heroin, alcohol- and nicotine-seeking.

DRUG RECEPTOR ROLE IN REINSTATEMENT CITATION
Cocaine AMPA Agonists promote reinstatement 9, 20, 21
Antagonists attenuate reinstatement 5,6, 21, 22
NMDA Antagonists in NAcc shell promote reinstatement 24
Antagonists (high dose) in NAcc core promote reinstatement 24
Antagonists (low dose) in NAcc core attenuate reinstatement 21,22
mGluR2/3 Agonists attenuate reinstatement 27,28,30
mGluR Indirect agonists attenuate reinstatement 12,13,17
mGluR1/5 Antagonists attenuate reinstatement 21,31
Heroin AMPA Antagonists attenuate reinstatement 38
mGluR2/3 Agonists attenuate reinstatement 39
mGluR Indirect agonists attenuate reinstatement 29
Alcohol mGluR2/3 Agonists attenuate reinstatement 40
mGluR1/5 Antagonists attenuate reinstatement 41
Nicotine mGluR2/3 Agonists attenuate reinstatement 47
mGluR1/5 Antagonists attenuate reinstatement 48,49,50