Figure 2.

Expansion of developing B cells in distinct strains of mice lacking AR or with ablation of AR function after castration. A, High numbers of precursor B220^low B cells in G-ARKO (C57BL6/FVB) (n = 5) compared with Wt (C57BL6/FVB) mice (n = 5). The absolute numbers of the B cells from BM (10⁶ cells per femur) are increased in the G-ARKO mice (far right). B, High numbers of precursor B220^low B cells in Tfm (C57B6/6J-A-Ta) (n = 4) compared with Wt mice (C57B6/6J-A-Ta) (n = 4). C, High numbers of precursor B220^low B cells in castrated BALB/c (n = 5) compared with Wt BALB/c mice (n = 5). D, DHT supplementation reduces B cells in bone marrow of castrated BALB/c mice (n = 5) but not in G-ARKO mice (n = 5), suggesting that AR mediates this effect. Cast, Castration.