Figure 4.
Stage of differentiation of B220+ cells in bone marrow and in periphery of G-ARKO, B-ARKO. A, Bone marrow cells from G-ARKO, B-ARKO, and Wt mice were analyzed for cell surface marker expression patterns using flow cytometry with markers B220, CD2, and IgM. Three populations of B220+ gated cells were observed: pro-B cells (B220+, CD2−, IgM−), pre-B cells (B220+, CD2+, IgM−) and immature B cells (B220+,CD2+, IgMlow). B, The subset distribution of B cells (B220+), in the spleens of G-ARKO, B-ARKO, and Wt mice.