Figure 1.

Effects of TCDD on mRNA expressions of diagnostic markers during the initial 72-h time period. MCF10A cells were treated with 10 nm TCDD for different time periods as indicated. The levels of mRNA expressions were assessed for CYP1A1 (panel A); Cox-2, MMP-2, CSF-1, and CYP19 (panel B); and IκB-α, TNF-α, and IL-8 (panel C). The results are expressed as fold of induction over control, and the statistically significant differences between the 0-min group and other time period groups are indicated by * (P < 0.05) or ** (P < 0.01).