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. 2009 Jan 15;23(4):549–558. doi: 10.1210/me.2008-0317

Figure 7.

Figure 7

Effects of cyclooxygenase inhibitor on the activation of PKA by TCDD. A, MCF10A cells were preincubated with or without 10 μm piroxicam for 30 min and then treated with 10 nm TCDD for different time periods as indicated. PKA activities were measured as described. The statistically significant differences between the control and treatment are indicated by * (P < 0.05) or ** (P < 0.01). B and C, MCF10A cells were preincubated with or without 10 μm piroxicam for 30 min and then treated with 10 nm TCDD for 24 h or 72 h. The mRNA induction levels of selected genes were measured. The results are expressed as folds of induction after TCDD treatment, and the statistically significant differences between the TCDD-only group and piroxicam+TCDD group are indicated by * (P < 0.05) or ** (P < 0.01).