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. 2009 Apr 17;284(16):10367–10375. doi: 10.1074/jbc.M807822200

FIGURE 2.

FIGURE 2.

Resistance of IRAK2-deficient mice to LPS-induced septic shock. A, age- and sex-matched wild type (n = 22) and IRAK2-deficient (n = 21) mice were injected intraperitoneally with LPS (20 mg/kg body weight). Survival was monitored for 7 days after LPS challenge. B, concentrations of TNFα, IL1β, IL 6, and IL 10 were measured by enzyme-linked immunosorbent assay in sera from wild type and IRAK2-deficient mice 0, 1.5, and 3.5 h after injection of LPS (4 mg/kg of body weight). The results shown are the means ± S.D. of triplicate determinations. *, p < 0.05.