Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of LPS-mediated IRAK2-dependent post-transcriptional control. Upon LPS stimulation in macrophages, IRAK4 is activated, leading to the modification and activation of IRAK1 and IRAK2. While IRAK1 and IRAK2 activate TAK1 and MEKK3 to mediate NFκB activation, the activated IRAK2 recruits kinases (MKK3/6, ERK, p38, MK2, and MNK1) and effector molecules (TRAF6, eIF4E, and TTP) to mediate mRNA stabilization and translation initiation.
