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SIK reduces lipogenic genes expression. A, effects of Ad-SIK1 or control (Ad-GFP) on lipogenic gene expression (Srebf1, Fasn, and Scd1) in mouse liver. B, effects of Ad-SIK1 RNA interference or control (Ad-US) on lipogenic gene expression (Srebf1, Fasn, and Acaca) in mouse liver. C, Western blot analysis showing protein levels for SIK1, ACC, FAS, and α-tubulin from mouse liver extracts as in A and B. Data in A and B represent mean ± S.D. (n = 3) (**, p < 0.01; *, p < 0.05, t test).
