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Structural basis for complement inhibition by S77, CRIg, and compstatin. The superposition of the C3b-S77 complex, the C3c-CRIg complex, and the C3c-compstatin complex shows that all three inhibitors recognize the same “face” of the complement protein; their binding sites are located on the opposite site of the TED position in C3b. C3b-C3c and S77 are colored as described in Fig. 2, CRIg is shown in red, and compstatin is depicted as purple sticks.
