TABLE 1.

Inhibition of different IPK family members by TNP

Name of enzyme	IP3-3KA	IPMK	IP6K1
Substrate (μm)	0.01		1000
Km of ATP (μm)a	10.8	17	1000
IC50 (μm)b	18.0	NDc	0.47
Ki (μm)d	17.9		0.24

^aValues for IP3-3KA were determined in our laboratory and in other laboratories (22), and values for IPMK and IP6K1 have been reported elsewhere (5, 6, 23, 24)

^bValues determined in this work

^cNot determined

^dK_i values were determined using the equation, K_i = IC₅₀/(1 + ([substrate]/K_m))