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Role of CaMKII in Aβ regulation of surface GluR1 clusters. A–C, immunocytochemical images of surface GluR1 staining in cultured cortical pyramidal neurons (DIV 18) transfected (GFP+) with a scrambled siRNA (A), CaMKII siRNA (B), or wild-type CaMKII (C) without (control) or with Aβ (1 μm) exposure for 3 days. D, cumulative data (mean ± S.E.) showing the density of surface GluR1 clusters in control or Aβ-treated neurons transfected with different constructs. *, p < 0.01, ANOVA.
