FIGURE 2.

Summary of structurally informative NMR data for varv F. Panel A shows the sequence (in a clockwise direction) and disulfide bonds as thick shaded lines between the cysteine residues (circled). Panels A and B, respectively, show short-range d_αN NOEs and d_NN NOEs. Black boxes represent sequential NOEs (the size of the box relates to the size of the NOE), whereas arcs represent NOEs between residues separated by 2 or 3 residues in the sequence. In panel B long-range NOE connectivities are shown as gray lines. Panel C focuses on the secondary structure. To illustrate the position of the residues in the cystine knot, three cysteines (Cys^IV, Cys^V, and Cys^VI) are highlighted with bold circles. The NOEs and predicted hydrogen bonds are included.