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Induction of extensions is independent of signaling by Rac, Cdc42, and Crk. After transfection with GFP-N17Rac1 (1 and 4), GFP-N17Cdc42 (2 and 5) or cotransfection with a Crk SH3 domain mutant (Crk-SH3*) and NLS-GFP (3 and 6), 388-Cbl–expressing cells were replated for 4 h in the presence of Y-27632. Anti-tubulin antibody (1–3) and GFP staining (4– 6) was then determined by confocal immunofluorescence microscopy. Bar, 50 μm.
