TABLE 1.
Regulation of the 40 most highly glucose repressed genes by Isc1p, mitochondrial function, Adr1p, Snf1p, and Cat8p
The genes whose expression ratio(s) in the parental strain relative to the mutant strain are more than 2-fold were described as genes that are regulated by the factor deficient in the mutant strain and expressed as boldface and underlined letters.
| Open reading frame | Gene name | I/R | ISC1/isc1 | Grande/petite | I/R | ADR1/adr1 | SNF1/snf1 | CAT8/cat8 | Regulating genes |
|---|---|---|---|---|---|---|---|---|---|
| YLR377c | FBP1 | 98.7 | 1.1 | 13.9 | 130.0 | 0.8 | 36.0 | 7.4 | Mit, SNF1, CAT8 |
| YKL217w | JEN1 | 1921.4 | 1.4 | 3.2 | 98.0 | 3.3 | 28.0 | 2.1 | Mit, ADR1, SNF1, CAT8 |
| YGR236c | SPG1 | 144.6 | 1.6 | 0.4 | 92.0 | 15.0 | 5.0 | 0.5 | ADR1, SNF1 |
| YKR097w | PCK1 | 67.3 | 0.9 | 0.5 | 92.0 | 1.4 | 180.0 | 3.6 | SNF1, CAT8 |
| YJR095w | SFC1 | 102.0 | 1.2 | 18.1 | 78.0 | 1.1 | 170.0 | 6.2 | Mit, SNF1, CAT8 |
| YIL057c | YIL057c | 2.4 | 0.6 | 0.4 | 77.0 | 16.0 | 8.9 | 0.8 | ADR1, SNF1 |
| YMR107w | SPG4 | 85.5 | 1.2 | 0.7 | 75.0 | 2.3 | 18.0 | 0.5 | ADR1, SNF1 |
| YCR010c | ADY2 | 144.6 | 2.9 | 26.0 | 72.0 | 20.0 | 32.0 | 9.3 | ISC1, Mit, ADR1, SNF1, CAT8 |
| YDR384c | ATO3 | 2.3 | 5.9 | 62.0 | 55.0 | 6.4 | 2.0 | 4.6 | ISC1, Mit, ADR1, CAT8 |
| YPL276w | YPL276w | 685.5 | 59.7 | 8.3 | 50.0 | 64.0 | 5.1 | 1.8 | ISC1, Mit, ADR1, SNF1 |
| YPR001w | CIT3 | 88.9 | 3.3 | 0.5 | 50.0 | 10.0 | 1.4 | 0.7 | ISC1, ADR1 |
| YGL205w | POX1 | 566.1 | 2.4 | 10.4 | 44.0 | 55.0 | 0.8 | 2.3 | ISC1, Mit, ADR1, CAT8 |
| YPR002w | PDH1 | 98.1 | 3.6 | 1.5 | 44.0 | 2.1 | 1.1 | 1.0 | ISC1, ADR1 |
| YAL054c | ACS1 | 87.0 | 2.8 | 6.1 | 43.0 | 9.0 | 30.0 | 3.5 | ISC1, Mit, ADR1, SNF1, CAT8 |
| YOR388c | FDH1 | 797.6 | 39.0 | 5.5 | 35.0 | 52.0 | 4.6 | 1.8 | ISC1, Mit, ADR1, SNF1 |
| YKL187c | YKL187c | 23.5 | 3.0 | 0.5 | 34.0 | 2.7 | 6.2 | 3.2 | ISC1, ADR1, SNF1, CAT8 |
| YDR256c | CTA1 | 114.8 | 3.6 | 7.0 | 34.0 | 16.0 | 7.6 | 3.3 | ISC1, Mit, ADR1, SNF1, CAT8 |
| YKR009c | FOX2 | 24.6 | 2.1 | 2.8 | 33.0 | 16.0 | 2.4 | 1.5 | ISC1, Mit, ADR1, SNF1 |
| YGR067c | YGR067c | 82.1 | 1.5 | 3.2 | 33.0 | 0.9 | 39.0 | 7.1 | Mit, SNF1, CAT8 |
| YNL195c | YNL195c | 22.2 | 0.6 | 0.3 | 29.0 | 3.0 | 7.7 | 0.8 | ADR1, SNF1 |
| YER065c | ICL1 | 43.5 | 1.3 | 18.8 | 28.0 | 0.4 | 77.0 | 20.0 | Mit, SNF1, CAT8 |
| YER024w | YAT2 | 44.5 | 1.4 | 0.8 | 26.0 | 0.6 | 5.6 | 2.0 | SNF1 |
| YGR243w | FMP43 | 23.8 | 1.2 | 1.5 | 26.0 | 2.8 | 6.1 | 0.6 | ADR1, SNF1 |
| YAR035w | YAT1 | 90.3 | 2.2 | 1.6 | 25.0 | 0.9 | 7.4 | 1.5 | ISC1, SNF1 |
| YMR206w | YMR206w | 69.4 | 1.0 | 0.3 | 25.0 | 1.2 | 5.9 | 1.0 | SNF1 |
| YIL160c | POT1 | 46.4 | 1.8 | 1.5 | 22.0 | 14.0 | 1.5 | 0.4 | ADR1 |
| YPR150w | YPR150w | 5.4 | 0.8 | 0.5 | 22.0 | 4.3 | 2.0 | 1.3 | ADR1, SNF1 |
| YLR174w | IDP2 | 92.0 | 1.4 | 2.2 | 21.0 | 0.9 | 16.0 | 2.5 | Mit, SNF1, CAT8 |
| YLR126c | YLR126c | 0.8 | 0.6 | 2.1 | 21.0 | 7.7 | 1.5 | 1.0 | Mit, ADR1 |
| YBR050c | REG2 | 22.2 | 1.5 | 0.2 | 21.0 | 1.5 | 42.0 | 5.0 | SNF1, CAT8 |
| YEL008w | YEL008w | 8.9 | 10.0 | 4.1 | 21.0 | 1.1 | 7.5 | 1.5 | ISC1, Mit, SNF1 |
| YPR006c | ICL2 | 24.9 | 4.2 | 13.4 | 21.0 | 7.0 | 4.0 | 2.1 | ISC1, Mit, ADR1, SNF1, CAT8 |
| YHL032c | GUT1 | 13.1 | 2.0 | 1.4 | 20.0 | 2.4 | 6.8 | 2.3 | ADR1, SNF1, CAT8 |
| YHR139c | SPS100 | 6.3 | 0.2 | 0.3 | 19.0 | 0.5 | 1.0 | 0.7 | |
| YPR151c | SUE1 | 2.3 | 0.6 | 0.9 | 18.0 | 3.8 | 1.9 | 1.2 | ADR1 |
| YLR267w | BOP2 | 17.3 | 0.6 | 0.2 | 17.0 | 0.4 | 0.9 | 0.1 | |
| YNR002c | ATO2 | 78.4 | 2.2 | 1.4 | 16.0 | 1.0 | 1.3 | 0.6 | ISC1 |
| YNL009w | IDP3 | 10.5 | 1.5 | 1.4 | 15.0 | 5.0 | 2.0 | 1.6 | ADR1 |
| YNL013c | YNL013c | 2.4 | 0.6 | 0.4 | 15.0 | 3.0 | 1.6 | 0.1 | ADR1 |
| YER179w | DMC1 | 7.8 | 2.3 | 3.9 | 14.0 | 7.0 | 1.8 | 0.9 | ISC1, Mit, ADR1 |