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. 2009 Apr 17;284(16):10947–10956. doi: 10.1074/jbc.M806960200

FIGURE 2.

FIGURE 2.

Absence of caspase-3 protects against diabetes induced by c-Myc activation without leading to islet dedifferentiation or tumor formation. Mice were injected daily with 1 mg of tamoxifen for 30 days. A, blood glucose profile of mice receiving daily tamoxifen injections (n = 3 per genotype, except n = 5 for c-Myc+Casp3-/-; p < 0.001 for all time points above and including day 2). B, synaptophysin, glucagon, and insulin immunostaining of islets following a 30-day c-Myc activation. C and D, decreased total islet area (C)(n = 4 per genotype; *, p = 0.019) and decreased islet number (D)(n = 4 per genotype; **, p = 0.01) in c-Myc+Casp3+/+ mice after prolonged c-Myc activation. E, total pancreatic area quantitation indicates no difference in pancreas size between genotypes. F, RT-PCR quantification of IL-1β transcript levels in islets after 2 days of c-Myc activation. -, +/+, c-Myc-; +, +/+, c-Myc+Casp3+/+ and c-Myc+Casp3+/-; +, -/-, c-Myc+Casp3-/-. Results represent means ± S.E.