FIGURE 8.
A, summarizing presentation of immunostainings of Wnt-5a and membrane-associated β-catenin in representative sections of human invasive breast carcinomas. Staining was done with a polyclonal rabbit antibody against human Wnt-5a (19) and an antibody directed against β-catenin. The tumors in the figure represents gradings 0 (lower) to 3 (upper) (see “Experimental Procedures” for description) for membrane-associated β-catenin and Wnt-5a (left) with magnifications representing the squared fields (right). B, the diagram represents the percentage of β-cateninhigh tumors (grading 2 and 3) in the different Wnt-5a groups (0, 1, 2, 3). The statistical Chi-square test was used and the linear to linear association between Wnt-5a and membrane-bound β-catenin was p = 0.004.