Table 2.
Genes coding for known secreted proteins differentially expressed in Akt-MSC versus control MSC under normoxic or hypoxic conditions
| Gene title | Gene symbol | GO biological process description |
|---|---|---|
| Inhibin beta-B | Inhbb | cell growth and/or maintenance |
| Bone morphogenetic protein 2 | Bmp2 | TGFbeta receptor signaling pathway /// embryonic development /// organogenesis /// cell fate commitment |
| A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) | Adamts5 | proteolysis and peptidolysis /// protein amino acid prenylation |
| kit ligand/stem cell factor | Kitl | cell adhesion /// germ-cell development |
| Proliferin | Plf | angiogenesis |
| Lipoprotein lipase | Lpl | lipid metabolism /// lipid catabolism |
| c-fos induced growth factor | Figf | regulation of cell cycle /// angiogenesis /// cell growth and/or maintenance /// cell proliferation |
| Immunoglobulin superfamily containing leucine-rich repeat | Islr | cell adhesion |
| Cysteine-rich motor neuron 1 | Crim1 | regulation of cell growth |
| Fibronectin 1 | Fn1 | acute-phase response /// cell adhesion /// metabolism /// wound healing |
| Secreted protein SST3 | SST3 | --- |
| Latent transforming growth factor beta binding protein 2 | Ltbp2 | extracellular transport /// protein secretion /// protein targeting /// transforming growth factor beta receptor signaling pathway |
| Arginyl aminopeptidase (aminopeptidase B) | Rnpep | proteolysis and peptidolysis |
| Thrombospondin 1 | Thbs1 | cell adhesion /// negative regulation of angiogenesis |
| Matrix metalloproteinase 11 | Mmp11 | proteolysis and peptidolysis /// collagen catabolism |
| Angiogenin | Ang | angiogenesis |
| Thrombospondin 2 | Thbs2 | cell adhesion |
| Mannan-binding lectin serine protease 1 | Masp1 | proteolysis and peptidolysis /// complement activation, classical pathway |
| Fibulin 5 | Fbln5 | cell adhesion |
| Chemokine (C-X-C motif) ligand 12 | Cxcl12 | chemotaxis /// immune response /// brain development /// regulation of cell migration /// T-cell proliferation |
| Carboxypeptidase E | Cpe | proteolysis and peptidolysis |
| Connective tissue growth factor | Ctgf | ossification /// angiogenesis /// regulation of cell growth /// DNA metabolism /// cell adhesion /// cell-matrix adhesion /// integrin-mediated signaling pathway /// FGF receptor signaling pathway /// cell migration |
| Platelet derived growth factor, alpha | Pdgfa | regulation of cell cycle /// cell growth and/or maintenance /// cell proliferation |
| Angiotensinogen | Agt | regulation of blood pressure |
| Chemokine (C-C motif) ligand 7 | Ccl7 | transport /// chemotaxis /// inflammatory response /// immune response /// signal transduction |
| Cysteine-rich protein 61 | Cyr61 | regulation of cell growth /// patterning of blood vessels /// chemotaxis /// cell adhesion |
| Osteoglycin | Ogn | growth factor activity |
| Chemokine (C-C motif) ligand 2 | Ccl2 | chemotaxis /// inflammatory response /// immune response /// signal transduction |
| Angiopoietin-like 4 | Angptl4 | angiogenesis /// cell differentiation /// cellular response to starvation /// multicellular organismal development /// negative regulation of apoptosis /// negative regulation of lipoprotein lipase activity /// positive regulation of angiogenesis /// positive regulation of lipid metabolic process /// response to hypoxia /// signal transduction |
| Insulin-like growth factor binding protein 4 | Igfbp4 | regulation of cell growth |
| Apolipoprotein D | Apod | transport |
| Mesoderm-specific transcript | Mest | proteolysis and peptidolysis /// xenobiotic metabolism /// response to toxin |
| Secreted frizzled-related sequence protein 1 | Sfrp1 | development |
| Angiopoietin 4 | Agpt4 | transmembrane receptor protein tyrosine kinase signaling pathway /// endoderm development |
| Matrix metalloproteinase 13 | Mmp13 | proteolysis and peptidolysis /// collagen catabolism |
| Superoxide dismutase 3, extracellular | Sod3 | superoxide metabolism |
| Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | Sema3c | development /// neurogenesis |
| Hepatocyte growth factor | Hgf | cellular morphogenesis /// proteolysis and peptidolysis /// cell proliferation |
| Leucine-rich repeat containing 17 | Lrrc17 | --- |
| Lysyl oxidase-like 2 | Loxl2 | aging /// cell adhesion /// protein modification process |
| Interferon, alpha-inducible protein | G1p2 | immune response |
| Secreted frizzled-related sequence protein 3 | Sfrp3 | development |
| Interferon-inducible GTPase 1 | Iigp1 | cytokine and chemokine mediated signaling pathway |
| Vascular endothelial growth factor A | Vegfa | regulation of cell cycle /// angiogenesis /// cell growth and/or maintenance /// cell proliferation |
| Adrenomedullin | Adm | neuropeptide signaling pathway |
| Adipsin | Adn | proteolysis and peptidolysis /// complement activation, alternative pathway |
| Pleiotrophin | Ptn | ossification /// learning /// cell proliferation /// bone mineralization |
| Serine (or cysteine) proteinase inhibitor, clade E, member 1 | Serpine1 | blood coagulation /// fibrinolysis |
| Secreted frizzled-related sequence protein 2 | Sfrp2 | development |