TABLE III.
HAZARD RATE RATIOS (RRs) FOR ENDOMETRIAL CANCER IN RELATION TO ALCOHOL INTAKE BY OTHER RISK FACTOR CATEGORIES IN THE MULTIETHNIC COHORT
| Total intake |
|||||
|---|---|---|---|---|---|
| Nondrinkers | <2 drink/day | ≥2 drinks/day | p trend | ||
| BMI < 25 | |||||
| No. cases | 67 | 43 | 20 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 1.00 (0.64, 1.56) | 2.88 (1.57, 5.31) | 0.013 | |
| BMI 25 to <30 | |||||
| No. cases | 52 | 29 | 5 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 1.12 (0.67, 1.86) | 1.22 (0.43, 3.44) | 0.617 | |
| BMI ≥ 30 | |||||
| No. cases | 77 | 27 | 4 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.84 (0.52, 1.35) | 1.34 (0.43, 4.11) | 0.759 | |
| Never HT | |||||
| No. cases | 106 | 41 | 8 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.93 (0.63, 1.37) | 1.41 (0.64, 3.12) | 0.825 | |
| Past HT | |||||
| No. cases | 35 | 21 | 7 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 1.08 (0.57, 2.06) | 2.96 (1.06, 8.28) | 0.130 | |
| Current ET | |||||
| No. cases | 11 | 7 | 3 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 2.49 (0.45, 13.85) | 20.01 (0.34, 11191.4) | 0.152 | |
| Current EPT | |||||
| No. cases | 44 | 30 | 11 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.99 (0.57, 1.71) | 1.86 (0.83, 4.15) | 0.269 | |
| Never smokers | |||||
| No. cases | 120 | 50 | 9 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 1.13 (0.78, 1.62) | 2.38 (1.13, 5.01) | 0.091 | |
| Past smokers | |||||
| No. cases | 63 | 41 | 14 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.98 (0.62, 1.52) | 1.95 (0.98, 3.88) | 0.205 | |
| Current smokers | |||||
| No. cases | 13 | 8 | 6 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.47 (0.14, 1.58) | 1.54 (0.33, 7.26) | 0.967 | |
| Nulliparous | |||||
| No. cases | 21 | 24 | 7 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 2.39 (1.16, 4.93) | 3.56 (1.20, 10.59) | 0.006 | |
| Parous | |||||
| No. cases | 175 | 75 | 22 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.91 (0.68, 1.22) | 1.82 (1.11, 2.99) | 0.275 | |
| OC never | |||||
| No. cases | 142 | 69 | 17 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 1.10 (0.80, 1.50) | 1.93 (1.10, 3.39) | 0.076 | |
| OC ever | |||||
| No. cases | 54 | 30 | 12 | ||
| Multivariate RR1 (95% CI) | 1.00 (referent) | 0.83 (0.50, 1.36) | 1.62 (0.76, 3.48) | 0.640 | |
1
RRs were stratified by age at recruitment, year of recruitment, race/ethnicity and study center and adjusted for education, body mass index, age at menarche, age at menopause, duration and type of hormone therapy use, duration of oral contraceptive use, parity, smoking history, diabetes, hypertension and vigorous physical activity when appropriate.