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. Author manuscript; available in PMC: 2009 Apr 10.
Published in final edited form as: Parasitology. 2009 Mar 5;136(5):567–577. doi: 10.1017/S0031182009005617

Table 5.

The effects of primary and secondary infections on immune parameters

Term Coefficient ta P valuea
IgE b Intercept −1.31 ± 0.31 −4.28 <0.001
Time (Day 21 p.s.i.) 0.513 ± 0.194 2.65 <0.01
Secondary dose (30 or 750 iL3s)c 0.639 ± 0.206 3.11 <0.01
Primary spp. (N. brasiliensis) 0.600 ± 0.314 1.91 0.06
Primary spp. (S. venezuelensis) 0.574 ± 0.314 1.83 0.07
Primary spp. (S. ratti, 30 iL3s) 0.866 ± 0.363 2.39 <0.05
Primary spp. (S. ratti, 750 iL3s) 1.18 ± 0.36 3.24 <0.01
IgG1 d Intercept −0.830 ± 0.133 −6.24 -
Time (Day 21 p.s.i.) 0.250 ± 0.189 1.32 0.19
Secondary dose (30 iL3s) −0.043 ± 0.177 −0.24 0.81
Secondary dose (750 iL3s) 0.019 ± 0.177 0.11 0.92
Primary spp. S. ratti (30 iL3s) 0.644 ± 0.209 3.08 <0.01
Primary spp. S. ratti (750 iL3s) 2.19 ± 0.21 10.5 <0.001
Time × Secondary dose (30 iL3s) 0.822 ± 0.250 3.29 <0.01
Time × Secondary dose (750 iL3s) 1.55 ± 0.25 6.13 <0.001
Time × Primary spp. S. ratti (30 iL3s) −0.116 ± 0.309 −0.38 0.71
Time × Primary spp. S. ratti (750 iL3s) −0.849 ± 0.296 −2.87 <0.01
RMCPII e Intercept −1.55 ± 0.34 −4.58 -
Secondary dose (30 or 750 iL3s)c 0.902 ± 0.182 4.97 <0.001
Time (Day 21 p.s.i.) 0.564 ± 0.469 1.2 0.23
Primary spp. (N. brasiliensis) 1.45 ± 0.39 3.75 <0.001
Primary spp. (S. venezuelensis) 1.14 ± 0.40 2.95 <0.01
Primary spp. (S. ratti) 1.79 ± 0.39 4.63 <0.001
Time × Primary spp. (N. brasiliensis) −1.56 ± 0.56 −2.76 <0.01
Time × Primary spp. (S. venezuelensis) −1.19 ± 0.56 −2.1 <0.05
Time × Primary spp. (S. ratti) −1.44 ± 0.56 −2.55 <0.05
IL4 MLN f Intercept −1.27 ± 0.27 −4.73 -
Secondary dose (30 iL3s) 0.969 ± 0.295 3.28 <0.01
Secondary dose (750 iL3s) 1.56 ± 0.30 5.30 <0.001
Primary spp. S. ratti (30 or 750 iL3s)g 0.646 ± 0.256 2.53 <0.05
IL13 MLN h Intercept −0.315 ± 0.242 −1.30 -
Time (Day 21 p.s.i.) −0.856 ± 0.255 −3.36 <0.01
Secondary dose (30 or 750 iL3s)c 1.27 ± 0.26 4.88 <0.001
IL13 spleen i Intercept −0.97 ± 0.21 −4.63 -
Secondary dose (30 or 750 iL3s)c 1.46 ± 0.26 5.67 <0.001
IFNγ MLNj Intercept −0.529 ± 0.318 −1.67 -
Time (Day 21 p.s.i.) 0.983 ± 0.259 3.79 <0.001
Primary spp. S. ratti (30 or 750 iL3s)g −0.628 ± 0.275 −2.28 <0.05
Secondary dose (30 or 750 iL3s)c 0.685 ± 0.275 2.49 <0.05
a

Significance of individual terms are presented as estimates against a t distribution. F tests from deletion tests are presented in the text.

b

2 × log-likelihood = −211.92 with 78 residual degrees of freedom

c

Factor levels for secondary dose were grouped such that animals receiving a dose of 0 were compared with those receiving either 30 or 750 S. ratti iL3s.

d

2 × log-likelihood = −98.70 with 73 residual degrees of freedom

e

2 × log-likelihood = −183.40 with 74 residual degrees of freedom

f

2 × log-likelihood = −74.56 with 32 residual degrees of freedom

g

Factor levels for primary dose were grouped such that animals receiving either PBS, N. brasiliensis or S. venezuelensis were compared with those receiving 30 or 750 S. ratti iL3s as a primary infection.

h

2 × log-likelihood = −65.88 with 29 residual degrees of freedom

i

2 × log-likelihood = −77.16 with 34 residual degrees of freedom

j

2 × log-likelihood = −79.89 with 32 residual degrees of freedom