Table 3.

BRCAPRO-Predicted Proportion of Deleterious BRCA1 or BRCA2 Mutations and Observed Proportion

Variable	No. of Probands	Proportion Data			Brier Score
		Expected (%)*	Observed†
			%	95% CI
Ethnicity
African American	104	23.3	30.8	22.1–40.6	0.208‡
Hispanic	130	15.9	12.3	7.2–19.2	0.089
Other	58	18.6	17.2	8.6-29.4	0.139‡
All probands	292	19.1	19.9	15.4–24.9	0.141‡
< 0.05	149	1.9	10.7	6.2–16.9
0.05 to < 0.10	25	7.2	8.0	1.0–26.0
0.10 to < 0.25	42	15.0	16.7	7.0–31.4
≥ 0.25	76	65.5	43.4	32.1–55.3
Single breast cancer families	120	7.1	11.7	6.5–18.8	0.124‡
< 0.05	92	2.0	10.9	5.3–19.1
0.05 to < 0.10	10	7.4	10.0	0.3–44.5
0.10 to < 0.25	9	15.0	11.1	0.3–48.2
≥ 0.25	9	51.0	22.2	2.8–60.0
Other families	172	27.4	25.6	19.2–32.8	0.153‡
< 0.05	57	1.8	10.5	4.0–21.5
0.05 to < 0.10	15	7.0	6.7	0.2–31.9
0.10 to < 0.25	33	15.0	18.2	7.0–35.5
≥ 0.25	57	59.9	46.3	34.0–58.9

NOTE. BRCAPRO is a BRCA carrier prediction model.

^*Calculated as BRCAPRO-predicted probability multiplied by 0.85.

^†95% confidence interval is for the true proportion.

^‡P < .01