Table A1.
Characteristics of Probands and Families by Study Center
| Characteristic | Study Center Location |
|||||||
|---|---|---|---|---|---|---|---|---|
| Philadelphia |
New York |
Salt Lake City |
Chicago |
|||||
| No. | % | No. | % | No. | % | No. | % | |
| Total No. of families/probands | 41 | 166 | 3 | 82 | ||||
| Female probands | 39 | 95.1 | 162 | 97.6 | 3 | 100 | 82 | 100 |
| Probands with unilateral breast cancer | 35 | 85.4 | 123 | 74.1 | 1 | 33.3 | 55 | 67.1 |
| Probands with bilateral breast cancer | 4 | 9.8 | 20 | 12.0 | 2 | 66.7 | 13 | 15.9 |
| Probands with ovarian cancer | 1 | 2.4 | 13 | 7.8 | 0 | 0 | 8 | 9.8 |
| Probands with BRCA1 deleterious mutation | 4 | 9.8 | 12 | 7.2 | 3 | 100 | 13 | 15.9 |
| Probands with BRCA2 deleterious mutation | 5 | 12.2 | 9 | 5.4 | 0 | 0 | 12 | 14.6 |
| Mutation-tested individuals | 41 | 218 | 9 | 125 | ||||
| Families with ≥ 2 individuals tested | 0 | 24 | 14.5 | 3 | 100 | 16 | 19.5 | |
| Families with oophorectomy | 9 | 22.0 | 38 | 23.9 | 3 | 100 | 5 | 6.1 |
| No. of individuals per family | ||||||||
| Mean | 19.8 | 15.7 | 37.3 | 21.1 | ||||
| SD | 7.2 | 9.3 | 7.1 | 8.0 | ||||
| No. of individuals with breast cancer per family | ||||||||
| Mean | 1.95 | 1.50 | 3.00 | 2.33 | ||||
| SD | 0.92 | 1.01 | 1.00 | 1.46 | ||||
| No. of individuals with bilateral breast cancer per family | ||||||||
| Mean | 0.20 | 0.15 | 1.00 | 0.30 | ||||
| SD | 0.46 | 0.36 | 1.00 | 0.54 | ||||
| No. of individuals with ovarian cancer per family | ||||||||
| Mean | 0.10 | 0.31 | 1.00 | 0.35 | ||||
| SD | 0.30 | 0.67 | 1.00 | 0.71 | ||||
Abbreviation: SD, standard deviation.