Table 4.
Geometric Means and Geometric Mean Ratios With 90% CIs for Erlotinib and OSI-420 Pharmacokinetic Parameters of 300 mg Patients to 150 mg Patients
| PK Parameter by Analyte | Geometric Mean for Erlotinib by Dose (mg) |
Geometric Mean Ratio |
|||
|---|---|---|---|---|---|
| 150 (n = 15) | 300 (n = 17) | 300 mg/150 mg (%) | 90% CI | P | |
| Erlotinib | |||||
| Cmax | 1.81 | 3.38 | 186.8 | 132.8 to 262.6 | .0041 |
| AUC0-tau | 19.5 | 44.0 | 225.5 | 152.9 to 332.6 | .0013 |
| C24 | 0.324 | 0.935 | 288.3 | 155.7 to 533.9 | .0066 |
| OSI-420 | |||||
| Cmax | 0.192 | 0.385 | 200.5 | 132.8 to 302.8 | .0076 |
| AUC0-tau | 2.11 | 4.99 | 236.5 | 146.9 to 380.9 | .0045 |
| C24 | 0.0356 | 0.0989 | 278.0 | 137.6 to 561.4 | .0195 |
Abbreviations: Cmax, maximum plasma concentration; AUC0-tau, area under the plasma concentration-time curve during the dosing interval; C24, trough erlotinib plasma concentration.