Table A1.
Grade 3 or 4 Hematologic and Biochemistry Toxicities per Treatment Arm That Were Considered Treatment Related by the Local Investigator
| Toxicity | Treatment Arm |
||
|---|---|---|---|
| Erlotinib (n = 54) | TMZ (n = 27) | BCNU (n = 27) | |
| WBC | 1 | 1 | 8 |
| ANC | 1 | 10 | |
| Platelets | 4 | 11 | |
| Hemoglobin | 1 | ||
| Any hematotoxicity | 1 | 4 | 13 |
| Creatinine | 1 | 2 | |
| Bilirubin | 2 | 1 | 2 |
| ALT | 1 | 2 | |
| Hyperkalemia | 1 | ||
| Hypokalemia | 2 | ||
| Rash/dermatologic | 6 | ||
| Diarrhea | 1 | ||
| Febrile neutropenia | 1 | ||
| Pain | 1 | ||
Abbreviations: TMZ, temozolomide; BCNU, carmustine; ANC, absolute neutrophil count.