Table 1.
Parameter values used in the spatial simulationsa
| Name | Symbol | Value | Units |
|---|---|---|---|
| Initial active MPF | minit | 0.0114 mt | concentration |
| Initial active cdc25 | cinit | 0.0090 ct | concentration |
| Initial active Myt1 | winit | 0.9374 wt | concentration |
| Initial Akt | ainit | 0.0 | concentration |
| MPF activation rate | k25 | 1.0/ ct | 1/(min·concentration) |
| MPF activation rate | k25 | 0.1/ ct | 1/(min·concentration) |
| MPF inactivation rate | kw | 10.0/ wt | 1/(min·concentration) |
| MPF inactivation rate | kw | 0.1/ ct | 1/(min·concentration) |
| Cdc25 activation rate | kMPFc | 1.0/ mt | 1/(min·concentration) |
| Cdc25 inactivation rate | vc | 0.125 | 1/min |
| Cdc25 activation Michaelis-Menten constant | KMPFc | 0.1 ct | concentration |
| Cdc25 inactivation Michaelis-Menten constant | Kc | 0.1 ct | concentration |
| Myt1 activation rate | vw | 0.1 | 1/min |
| Myt1 inactivation rate | kMPFw | 2.0/ mt | 1/(min·concentration) |
| Akt-dependent Myt1 inactivation rate | k | 1.0 | 1/(min·concentration) |
| Myt1 activation Michaelis-Menten constant | KMPFw | 0.3 wt | concentration |
| Myt1 inactivation Michaelis-Menten constant | Kw | 0.3 wt | concentration |
| Akt flux density | Ja | 50.0 | concentration·μm/s |
| Akt flux duration | τ | 3 | min |
| MPF diffusion coefficient | Dm | 180 | μm2/min |
| Cdc25 diffusion coefficient | Dc | 180 | μm2/min |
| Akt diffusion coefficient | Da | 180 | μm2/min |
a
As in Novak & Tyson (1993), parameters are normalized to the total concentrations of MPF, Cdc25, and Myt1 (mt, ct, wt, respectively), which were given the value of 1 in the simulations