Table 1.

Summary of reasons for and timing of participant withdrawal from the study

	Arm 1		Arm 2
Reason for withdrawal	Days 1–14 Saquinavir/Ritonavir (N = 14)	Days 15–28 Saquinavir/Ritonavir + Rifampin (N = 8)	Days 1–14 Rifampin (N = 14)	Days 15–28 Rifampin + Saquinavir/Ritonavir (N = 9)
Adverse event	1	1	—	6
Consent withdrawn	1	—	1	1
Premature study termination*	4†	7	4†	2
Total number discontinued	6	8	5	9

^*At the time of study termination, these patients were still receiving trial treatment.

^†Two participants discontinued prior to receiving 14 days of the study drug and two participants received the full 14 days and completed a full PK profile.