Table 2.
Steady-state pharmacokinetic parameters measured/estimated on day 14 of the study
| N | Cmax(µg/mL) | Tmax(h) | AUCτ(µg·h/mL) | (h) | |
|---|---|---|---|---|---|
| Saquinavir | 10 | 4.54 | 4.00 | 29.1 | 5.55 |
| (44.5) | (3.00–6.00) | (54.8) | (18.3) | ||
| Ritonavir | 10 | 1.72 | 4.00 | 10.5 | 4.32 |
| (30.6) | (2.00–5.00) | (40.2) | (29.5) | ||
| Rifampin | 11 | 9.76 | 1.00 | 37.3 | 1.58 |
| (40.0) | (0.98–4.00) | (23.0) | (21.8) | ||
| Desacetyl-rifampin | 11 | 0.807 | 2.00 | 4.21 | 2.15 |
| (43.7) | (1.00–4.00) | (40.2) | (30.0) |
Median (min–max) for Tmax; geometric mean (CV%) for other parameters; τ = 12 hours for saquinavir/ritonavir and 24 hours for rifampin.