Table 2.

[50]Receptors Identified for the Mammalian Bioactive Fatty Acid Amides^a

A. N-Acylethanolamines
NAE	Receptors(s)	Reference
Anandamide	CB1, CB2, PPARα, PPARγ, TRPV1, and TRPM8	[6,13-16]
N-Dihomo-γlinolenoylethanolamine	CB1 and CB2	[119]
5Z,8Z,11Z- Eicosatrienoylethanolamine	CB1 and CB2	[119]
N-Oleoylethanolamine	PPARα, PPARγ, TRPV1, and GPR119	[6,15,24]
N-Palmitoylethanolamine	PPARα, GPR55	[15,27]
N-Linolenoylethanolamine	TRPV1	[6]
N-Linoleoylethanolamine	TRPV1	[6]
B. N-Acyldopamines
NDA	Receptors(s)	Reference
N-Arachidonoyldopamine	CB1, TRPV1, and non-CB1/CB2 GPCR (in the aorta)	[38,39,41]
N-Oleoyldopamine	PPARα, PPARγ, and TRPV1	[38,39]
C. N-Acylamino acidsb,c
NAA Receptors(s)	Reference	N-Arachidonoyltaurine
N-Arachidonoyltaurine	TRPV1 and TRPV4	[74]
N-Arachidonoylglycinec	GPR18	[75]
D. Primary Fatty Acid Amides
PFAM	Receptors(s)	Reference
Oleamide	GABAA receptor, 5-HT2A, 5-HT2C, and 5-HT7	[120-122]

^aIn some cases, the indicated fatty acid amide has not been demonstrated to bind to the listed target by direct binding, but instead has been shown to be an agonist or antagonist to the target using a reporter assay. For exact details, the reader is pointed to the cited references.

^bWhile N-acetylglutamate is not formally a fatty acid amide, this N-acylamino acid binds a protein target as it is an allosteric activator of carbamoylphosphate synthetase I.

^cFatty acid conjugation to amino acids serves largely in the detoxification and execretion of xenobiotic carboxylates. Thus, many of the N-acylamino acids are likely to bind to a membrane-bound transporter. For example, Wiles et al. [78] have recently shown that N-arachidonoylglycine inhibits the GLYT2a glycine transporter.